49,90
€
inkl. MwSt
- Verlag: Mensch & Buch
- Genre: keine Angabe / keine Angabe
- Seitenzahl: 160
- Ersterscheinung: 26.08.2024
- ISBN: 9783967292428
Transfer von Δ9-Tetrahydrocannabinol (Δ9-THC) und anderen Cannabinoiden aus nutzhanfhaltigen Futtermitteln in die Milch von Kühen
"Transfer of Δ9-tetrahydrocannabinol (Δ9-THC) and other cannabinoids from feed containing industrial hemp into the milk of cows"
Interest in the use of industrial hemp (legally cultivable hemp with a maximum tetrahydrocannabinol content of 0.3%) is growing, and in recent years many novel hemp products have been launched - including animal feed. Industrial hemp contains cannabinoids. Some of these have psychoactive effects in humans and animals (e.g., Δ9-tetrahydrocannabinol, Δ9-THC) or other pharmacological effects (e.g., cannabidiol, CBD). So far, it was unclear to what extent these cannabinoids are transferred from feed containing industrial hemp into products of animal origin and whether this poses a risk to the consumer.
In the present study, "Transfer of Δ9-tetrahydrocannabinol (Δ9-THC) and other cannabinoids from feed containing industrial hemp into the milk of cows", the results of a feeding trial with industrial hemp silage in ten lactating dairy cows are presented. Initially, part of the corn silage in the animals' feed ration was replaced for seven days by industrial hemp silage made from the entire hemp plant (GP-silage, very low cannabinoid concentration). This was followed by six days of partial replacement of corn silage with industrial hemp silage consisting only of leaves, inflorescences and seeds of the plant (BBS silage, higher cannabinoid concentration). Feeding was done in two dosages (group 1: low industrial hemp content; group 2: high industrial hemp content). During the experiment, milk and blood samples were obtained and the vital parameters and behavior of the cows were recorded. Analysis was performed by a liquid chromatography-tandem mass spectrometry-based method (HPLC-MS/MS), which allowed differentiation between psychoactive Δ9-THC and its non-psychoactive precursor Δ9-tetrahydrocannabinolic acid (Δ9-THCA).
Transfer rates of 0.24 ± 0.04% and 0.15 ± 0.05% from feed to milk were calculated for Δ9-THC and CBD, respectively. In different exposure scenarios calculated using the EFSA-RACE tool, several consumer groups exceeded the acute reference dose (ARfD) for Δ9-THC when milk and dairy products were consumed and industrial hemp silage was used to feed dairy cows. The exceedance was most pronounced in children when BBS-silage was used. In terms of animal health, feeding the low-cannabinoid GP-silage resulted in no significant effects in cows, whereas feeding the high-cannabinoid BBS-silage resulted in significant reductions in heart and respiratory rates, impaired movement coordination, reddened eyes, nasal secretion, hypersalivation, and pronounced tongue play.
Interest in the use of industrial hemp (legally cultivable hemp with a maximum tetrahydrocannabinol content of 0.3%) is growing, and in recent years many novel hemp products have been launched - including animal feed. Industrial hemp contains cannabinoids. Some of these have psychoactive effects in humans and animals (e.g., Δ9-tetrahydrocannabinol, Δ9-THC) or other pharmacological effects (e.g., cannabidiol, CBD). So far, it was unclear to what extent these cannabinoids are transferred from feed containing industrial hemp into products of animal origin and whether this poses a risk to the consumer.
In the present study, "Transfer of Δ9-tetrahydrocannabinol (Δ9-THC) and other cannabinoids from feed containing industrial hemp into the milk of cows", the results of a feeding trial with industrial hemp silage in ten lactating dairy cows are presented. Initially, part of the corn silage in the animals' feed ration was replaced for seven days by industrial hemp silage made from the entire hemp plant (GP-silage, very low cannabinoid concentration). This was followed by six days of partial replacement of corn silage with industrial hemp silage consisting only of leaves, inflorescences and seeds of the plant (BBS silage, higher cannabinoid concentration). Feeding was done in two dosages (group 1: low industrial hemp content; group 2: high industrial hemp content). During the experiment, milk and blood samples were obtained and the vital parameters and behavior of the cows were recorded. Analysis was performed by a liquid chromatography-tandem mass spectrometry-based method (HPLC-MS/MS), which allowed differentiation between psychoactive Δ9-THC and its non-psychoactive precursor Δ9-tetrahydrocannabinolic acid (Δ9-THCA).
Transfer rates of 0.24 ± 0.04% and 0.15 ± 0.05% from feed to milk were calculated for Δ9-THC and CBD, respectively. In different exposure scenarios calculated using the EFSA-RACE tool, several consumer groups exceeded the acute reference dose (ARfD) for Δ9-THC when milk and dairy products were consumed and industrial hemp silage was used to feed dairy cows. The exceedance was most pronounced in children when BBS-silage was used. In terms of animal health, feeding the low-cannabinoid GP-silage resulted in no significant effects in cows, whereas feeding the high-cannabinoid BBS-silage resulted in significant reductions in heart and respiratory rates, impaired movement coordination, reddened eyes, nasal secretion, hypersalivation, and pronounced tongue play.
Dieses Produkt bei deinem lokalen Buchhändler bestellen
Meinungen aus der Lesejury
Es sind noch keine Einträge vorhanden.